GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs1577917 | 1 | rs12663690 | chr6:86640162 | SNHG5 | chr6:86386726-86388451:- | 0.51 | 8.94 | 1.7E-17 | Response to antipsychotic treatment |
| BLCA | cis | rs1577917 | 1 | rs12664335 | chr6:86597774 | SNHG5 | chr6:86386726-86388451:- | 0.52 | 9.38 | 5.71E-19 | Response to antipsychotic treatment |
| BLCA | cis | rs1577917 | 1 | rs12665321 | chr6:86769289 | SNHG5 | chr6:86386726-86388451:- | -0.53 | -9.25 | 1.56E-18 | Response to antipsychotic treatment |
| BLCA | cis | rs1499614 | 1 | rs1267817 | chr7:66110040 | CCT6P1 | chr7:65216092-65228661:+ | 0.34 | 4.6 | 5.78E-6 | Gout |
| BLCA | cis | rs1499614 | 1 | rs1267818 | chr7:66107024 | CCT6P1 | chr7:65216092-65228661:+ | 0.35 | 4.78 | 2.49E-6 | Gout |
| BLCA | cis | rs2243480 | 1 | rs1267820 | chr7:66050295 | CCT6P1 | chr7:65216092-65228661:+ | 0.37 | 4.89 | 1.48E-6 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs12698509 | chr7:65418876 | CCT6P1 | chr7:65216092-65228661:+ | 0.32 | 4.5 | 9.19E-6 | Diabetic kidney disease |
| BLCA | cis | rs12748152 | 1 | rs12741472 | chr1:27221609 | GPN2 | chr1:27205873-27216869:- | 0.47 | 3.96 | 8.9E-5 | HDL cholesterol;Triglycerides;LDL cholesterol |
| BLCA | cis | rs12748152 | 1 | rs12752711 | chr1:27250258 | GPN2 | chr1:27205873-27216869:- | 0.47 | 3.96 | 8.9E-5 | HDL cholesterol;Triglycerides;LDL cholesterol |
| BLCA | cis | rs2275426 | 1 | rs12760175 | chr1:46447840 | CCDC163P | chr1:45960581-45965646:- | -0.32 | -5.83 | 1.19E-8 | Body mass index |
| BLCA | cis | rs7927771 | 1 | rs12787330 | chr11:47812311 | C1QTNF4 | chr11:47611216-47615961:- | -0.3 | -5.53 | 5.92E-8 | Subjective well-being |
| BLCA | cis | rs12787909 | 1 | rs12787909 | chr11:117546482 | ARCN1 | chr11:118443102-118473745:+ | 0.62 | 5.24 | 2.61E-7 | Lipoprotein (a) - cholesterol levels |
| BLCA | cis | rs12787909 | 1 | rs12787909 | chr11:117546482 | ATP5L | chr11:118272104-118280561:+ | 0.42 | 3.88 | 0.000123 | Lipoprotein (a) - cholesterol levels |
| BLCA | cis | rs12787909 | 1 | rs12787909 | chr11:117546482 | UBE4A | chr11:118230302-118269924:+ | 0.56 | 4.65 | 4.51E-6 | Lipoprotein (a) - cholesterol levels |
| BLCA | cis | rs302668 | 1 | rs12800378 | chr11:87865942 | RAB38 | chr11:87846431-87908599:- | 0.25 | 4.12 | 4.72E-5 | Frontotemporal dementia |